Different attacks can be performed by pushing up or down or running in combination with one of the three attack buttons. Characters have three different types of attacks: light attacks, which are weak but quick and can be used to perform combos strong attacks, which are slower but do more damage and knock opponents back further and special attacks, the properties of which vary by character. Movement takes place on a two-dimensional plane, with characters able to move around by running, jumping, double-jumping, or performing a mid-air dash in any of eight directions. Each stage offers a different layout, with some also having additional hazards that can cause damage to the characters.
Nickelodeon All-Star Brawl 2 is a platform fighter, with players battling on different stages and attempting to knock their opponents outside the boundaries of the arena.